Spring 2010

Noon
Hermes A. Kontos Medical Sciences Building Auditorium

January

Jan. 7

Promotion and Prescribing

Adriane Fugh-Berman, M.D.
Associate professor
Department of Physiology and Biophysics
Georgetown University Medical Center

Following this grand rounds presentation, participants will be able to:

  • Identify at least three methods used by drug reps to influence prescriptions
  • Recognize three techniques, besides advertising, that are used to market pharmaceuticals
  • Discuss how industry-supported CME programs may potentially work as advertising

Jan. 14

A Brief History of Nonalcoholic Steatohepatitis

Arun J. Sanyal, M.D.
Charles M. Caravati Professor in Gastroenterology and chair
Division of Gastroenterology, Hepatology, and Nutrition
Department of Internal Medicine
VCU School of Medicine

Through this grand rounds presentation, participants will learn about:

  • Pathogenesis of NASH
  • Prevalence and Burden of Liver Disease
  • Treatment of NASH

Jan. 21

Expand the Pharyngitis Paradigm for Adolescents and Young Adults

Robert M. Centor, M.D., FACP
Professor
Division of General Internal Medicine
Associate dean
Huntsville Regional Medical Campus
University of Alabama School of Medicine

Following this grand rounds presentation, participants will be able to:

  • Describe the morbidity and mortality that is associated with Lemierre Syndrome that can result from Fusobacterium necrophorum pharnygitis
  • Examine rationales for expanding diagnostic paradigms to include Fusobacterium necrophorum in addition to group A Streptococcus in adolescents with pharyngitis
  • Treat adolescents and young adults aggressively with antibiotics for F. necrophorum infections

Jan. 28

Surgical Options in IDDM: Pancreas vs. Islet Transplantation

Amit Sharma, M.D., M. Phil.
Assistant professor of surgery
Division of Transplant Surgery
Department of Surgery
VCU School of Medicine

Following this grand rounds presentation, participants will be able to:

  • List two surgical options for the Type 1 diabetic
  • List three benefits of pancreas transplantation
  • Identify three contraindications to islet cell transplant

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February

Feb. 4

Psychiatric Genetics: A Current Perspective

Kenneth S. Kendler, M.D.
Rachel Brown Banks Distinguished Professor in Psychiatry
Department of Psychiatry
VCU School of Medicine

Following this grand rounds presentation, participants will be able to:

  • Understand the basic results of paradigm 1, or basic genetic epidemiology, showing differences across psychiatric disorders
  • Understand the basic principles of paradigm 2, or advanced genetic epidemiology, including concepts of genotype environment correlation, and genotype environment interaction
  • Understand the principle of wide association and an overview of what the current patterns of findings are in complex diseases

Feb. 11

Clinicopathologic Conference: A 66-Year-Old Man with Syncope and Flushing

Lenore M. Buckley, M.D., M.P.H.
Professor
Division of Rheumatology, Allergy, and Immunology
Department of Internal Medicine
VCU School of Medicine
Review the CPC Protocol [PDF]

Following this grand rounds presentation, participants will be able to:

  • Recognize etiologies and diagnosis from the clinicopathologic case presented
  • Observe an experienced clinician's diagnostic reasoning process

Feb. 18

Wampler Lecture
Sponsored by the Division of Hematology, Oncology and Palliative Care

Problems of design, analysis, reporting and interpretation of randomized clinical trials: Examples from the cancer literature that are relevant to all branches of medicine

Ian F. Tannock, M.D., Ph.D.
Daniel E. Bergsagel Professor of Medical Oncology
Princess Margaret Hospital and University of Toronto
Canada

Following this grand rounds presentation, participants will be able to:

  • Explain how clinical trials of different types form a hierarchy of levels of evidence
  • Describe how sponsorship of clinical trials has changed over time
  • Explain the presence of publication bias
  • Elucidate the difference between statistical significance versus clinical importance of findings
  • Describe potential flaws of analyzing survival using a hazards ratio
  • Discuss the importance of how end points are defined in a randomized controlled trial and the impact on results
  • Explain the role of cost-effectiveness in future randomized controlled trials

Feb. 25

Koch’s Other Bacillus: Anthrax in the Post-Antibiotic Era

Jeffrey M. Tessier, M.D.
Assistant professor
Division of Infectious Diseases
Department of Internal Medicine
VCU School of Medicine

Following this grand rounds presentation, participants will be able to:

  • Explain the history of Robert Koch's discovery of Bacillus anthracis as the causative agent of anthrax
  • Discuss the pathogenesis and clinical features of human anthrax
  • Identify advances in the biology and treatment of anthrax

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March

March 4

The Great Debate: Duty Hours

Stephanie A. Call, M.D., M.S.P.H.
Associate professor
Program director
Internal Medicine Residency Training Program
Associate chair for education
Department of Internal Medicine
VCU School of Medicine

vs.

Lisa K. Brath, M.D., FCCP
Associate professor of medicine
Program director, Pulmonary-Critical Care Fellowship
VCU School of Medicine
Medical director, Respiratory Care Services
MCV Hospitals and Physicians

Following this grand rounds presentation, participants will be able to:

  • Identify positive consequences of work hour restrictions in GME programs
  • Identify negative consequences of work hour restrictions in GME programs
  • Formulate an informed opinion on the issue of work hour restrictions in GME programs

March 11

Crohn’s Disease: Time to Refine

Stephen J. Bickston, M.D., AGAF
Professor of internal medicine
Director, Inflammatory Bowel Disease Center
Associate chair for gastroenterology
VCU School of Medicine

Following this grand rounds presentation, participants will will advance in their understanding of:

  • Risks and benefits of common treatments
  • Risks and benefits of some common diagnostic techniques

March 18

Cardiac Reperfusion Injury: The Dark Side of Mitochondria

Edward J. Lesnefsky, M.D.
Professor
Division of Cardiology
Department of Internal Medicine
VCU School of Medicine
Chief of cardiology
McGuire VA Medical Center

Following this grand rounds presentation, participants will be able to:

  • Understand that a substantial portion of cardiac injury results from processes that occur during the early reperfusion phase, following the restoration of blood flow to treat acute myocardial infarction
  • Appreciate that abnormal intracellular metabolism by cardiac mitochondria damaged during the period of ischemia is a major mechanism of cardiomyocyte death during reperfusion
  • Consider that cytoprotective mitochondrial-based “intervention” during early reperfusion has the potential to compliment reperfusion from coronary intervention to further limit infarct size compared to coronary stent therapy alone

March 25

Glycemic Control in Diabetes and Cardiovascular Disease: Are We Pushing Too Hard?

Edmond P. “Trey” Wickham, M.D.
Assistant professor
Division of Endocrinology and Metabolism
Department of Internal Medicine
VCU School of Medicine

Through this grand rounds presentation the speaker will:

  • Review epidemiologic associations between diabetes/glucose intolerance and cardiovascular disease
  • Highlight the study design and results of recent large randomized, control trials investigating the effects of glycemic control on cardiovascular disease
  • Summarize the relative impact of glycemic control in preventing cardiovascular events compared with other risk factor modification in patients with diabetes
  • Discuss the implications of these studies on clinical diabetes care

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April

April 1

Thomas Lecture
Sponsored by Rheumatology, Allergy, and Immunology
Cytokine Signaling Immunoregulation: Therapeutic and Basic Considerations

John O’Shea, M.D.
Scientific director
Molecular Immunology and Inflammation Branch
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Institutes of Health
Department of Health and Human Services

Following this grand rounds presentation, participants will be able to:

  • Consider the implications of pharmacologically targeting Janus kinases
  • Understand the roles of STATs in Th17 differentiation
  • Discuss the relationship between STATs and epigenetic control of helper differentiation

April 8

Dr. Carolyn McCue Woman Cardiologist of the Year Award Lecture
Genomic Medicine: Insights from a Premature Aging Syndrome

Elizabeth G. Nabel, M.D.
President, Brigham and Women’s Hospitals
Professor of medicine, Harvard Medical School
Former director, National Heart, Lung and Blood Institute

Following this grand rounds presentation, participants will be able to:

  • Describe the genetic aspects of Progeria
  • List consequences of Progeria
  • Discuss cardiovascular risk in Progeria

April 15

Orhan Muren Lectureship
Sponsored by the Division Pulmonary Disease and Critical Care Medicine
Sepsis: New Molecular Insights into Multiple Organ Dysfunction Syndrome

Claude A. Piantadosi, M.D.
Professor of Medicine and Pathology
Duke University Medical Center

Through this grand rounds presentation, the speaker will:

  • Update on the scope and importance of severe sepsis in the ICU and the difficult aspects of targeted therapy for sepsis-induced multiple organ dysfunction syndrome (MODS)
  • Introduce new concepts in the molecular pathogenesis of MODS
    • Tissue, cell and molecular damage mechanisms, and major recovery/repair pathways
    • Assessment of impact on MODS
  • Provide a context and rationale for resuscitative and other supportive strategies for improving organ recovery in MODS

April 22

Clinicopathologic Conference (CPC)

Khoi Do, M.D.
Assistant professor
Division of General Internal Medicine
Department of Internal Medicine
VCU School of Medicine
CPC Protocol [PDF]

Following this grand rounds presentation, participants will be able to:

  • Recognize etiologies and diagnosis from the clinicopathologic case presented
  • Observe an experienced clinician's diagnostic reasoning process

April 29

VCU School of Medicine Educational Climate

Isaac K. “Ike” Wood, M.D., FAACAP
Senior associate dean for medical education and student affairs
Professor of psychiatry and pediatrics
VCU School of Medicine

Shawna J. Perry, M.D.
Director for patient safety systems engineering
VCU Health System
Associate professor and associate chair
Department of Emergency Medicine
VCU School of Medicine

Following this grand rounds presentation, participants will be able to:

  • Delineate the incidence of student mistreatment in the VCU Health System including most frequent forms of mistreatment, most likely offenders and department with highest rates
  • Explain how a hostile educational environment impacts education and patient safety
  • Reference legislation, policy and procedures that govern the educational environment
  • Define employer and employee responsibilities in assuring a respectable workplace

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May

May 6

Annual Markham Award Lecture
Sponsored by the Division of General Medicine
Our Parents, Ourselves: Getting the Healthcare We Need and Want in Late Life

Julie P.W. Bynum, M.D., M.P.H.
Assistant professor of medicine and community and family medicine
Dartmouth Medical School

Following this grand rounds presentation, participants will be able to:

  • Describe what we have and are learning through variations research about health care and the role of primary care
  • Evaluate what we currently deliver to elderly populations and how that care fits with this population’s needs and wants
  • Discuss opportunities in practice and in health reform to realign our practice with patient-centered goals

May 13

William Blackard Lecture
Sponsored by the Divison of Endocrinology and Metabolism
Osteoporosis: New Targets for Building Bone

Robert W. Downs Jr., M.D.
Professor of medicine and acting chair
Division of Endocrinology and Metabolism
Department of Internal Medicine
VCU School of Medicine

Following this grand rounds presentation, participants will be able to:

  • Describe the process of bone remodelling that results in osteoporosis
  • Critique the effectiveness and safety of existing osteoporosis treatment
  • Identify new targets for osteoporosis therapy based on recent research on bone biology

May 20

EM-IM-Surgery Conference

Stephanie A. Call, M.D., M.S.P.H.
Associate professor
Program director
Internal Medicine Residency Training Program
Associate chair for education
Department of Internal Medicine
VCU School of Medicine

Tim Evans, M.D.
Associate professor
Program director
Emergency Medicine Training Program
Department of Emergency Medicine
VCU School of Medicine

Brian J. Kaplan, M.D.
Associate professor
Program director
General Surgery Residency Training Program
Department of Surgery
VCU School of Medicine

Following this grand rounds presentation, participants will be able to:

  • Identify specifics of a case requiring multi-disciplinary intervention and coordination of care
  • Explain factors which make the case complex and challenging
  • Outline steps to improve outcome and quality of care for similar cases

May 27

Targeting the Intrinsic Apoptotic Pathway: A New Approach to Cancer Therapy

Geoffrey W. Krystal, M.D., Ph.D.
Professor and chair
Division of Hematology/Oncology
McGuire VA Medical Center

Following this grand rounds presentation, participants will be able to:

  • Understand the role of apoptosis in health and disease
  • Understand the regulation of apoptosis
  • Understand the mechanism of action of BH3 mimetic drugs

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June

June 3

Housestaff Research Presentations

Haeseong Park, M.D., M.P.H.
Magnesium Supplements for Hot Flashes in Breast Cancer Patients: A Pilot Phase II Trial

Roshi Robati, M.D.
Interleukin-1 blockade ameliorates left ventricular remodeling following ST-segment elevation acute myocardial infarction — the VCU-ART pilot study

Shaun Bhatty, M.D.
Any Organ Not Affected?

Learning objectives
Following this grand rounds presentation, participants will be able to:

  • Gain an appreciation for the breadth and depth of scholarly activities for resident trainees
  • Gain exposure to several unique case presentations for the inpatient setting at the VCU Medical Center
  • Recognize the complexity of patient pathology in the educational VCU Medical Center setting

June 9

Interleukin-1 and the Auto-Inflammatory Diseases

Charles Dinarello, M.D.
Professor of medicine
School of Medicine
University of Colorado at Denver

Following this grand rounds presentation, participants will be able to:

  • Distinguish between the dysfunctional cell in autoimmune immune diseases from the dysfunctional cell in auto-inflammatory diseases
  • Understand the treatment options for auto-inflammatory diseases
  • Understand the inflammatory nature of Type 2 diabetes

Location change: Sanger Hall, Room 1-044

Grand rounds will resume on Sept. 2, 2010.

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